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Dr. P .R. Manish Kumar

Professor, Head & Co-ordinator

 

Address:  Professor, Former Co-ordinator & Head ( 2008-2010; 2012-2014)
Dept. of Biotechnology ,University of Calicut

Residence: ‘Ananyam’, Vidya Nagar, Kohinoor
Thenhipalam P.O.Malappuram Dt
Kerala - 673 636

Off : 0494 2407404
Res : 0494-2402771
Mobile : +91-9447760771

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Qualifications : M.Sc., Ph.D.


Specialization : Cell and Molecular Biology (Ph.D.); Recombinant DNA Technology (PDF)

 
ACHIEVEMENTS:
  1. Awarded JRF on the basis of National Test conducted by C.S.I.R. (Govt. of India)
  2. Awarded Ph.D. in 1991 - (Cell & Molecular Biology Division, Zoology Dept, University of Calicut) – Area of research - Cell cycle regulation in naturally synchronous microbial cultures of slime mold – Physarum polycephalum.
  3. Awarded - Dept. of Biotechnology (Govt. of India) sponsored Research Associateship under‘ Post-doctoral Training Program in Biotechnology’ – Cloning and sequencing of cell cycle related gene sequences from silkworm-Bombyx mori ’ [ 1992-’94 -Microbiology and Cell Biology Laboratory, Indian Institute of Science, Bangalore ] ; Lecturer – ’94-’96 in college affiliated to University of Calicut.
    •  Undergone Specialized Training in
    •  Electron Microscopy ( AIIMS, N. Delhi)
    •  Radiotracer techniques (BARC, Mumbai)
    •  Basic and advanced molecular biology and recombinant DNA techniques
          ( Univ. of Calicut; IISc Bangalore)
    •  Animal cell culture ( Reliance Life Sciences, Navi Mumbai)
    •  Advances in Biotechnology ( TERI, N.Delhi)
  4. Awarded ‘Best Subject Expert for the year 2000’ by University Grants Commissionfor the Educational video on DNA Fingerprinting entitled ‘DNA evidence’ produced by Audiovisual Research Centre ( AVRC)
  5. Co- Principal Investigator in DBT ( Govt. of India) sponsored research project (2012-2015) with a total budget of Rs. 47.39 lakhs on ‘Screening for antiproliferative and G2 abrogating activity in endemic species of Zingiberaceae family of plants using Physarum polycephalum and human normal and cancer cell lines’.
MEMBERSHIP/PROFESSIONAL AFFILIATIONS
  • NATIONAL
  1. Served as Chairman, Board of studies ( Single Board) in Genetics, Univ. of Calicut
  2. Member – Board of Studies in Biotechnology, Univ. of Calicut.
  3. Served as DBT (Govt. of India) nominee – Institutional Biosafety Committee - at Indian Institute of Spices Research (IISR), Calicut.
  4. External subject Expert nominee– Research Admission Committee – IISR, Calicut; Department of Biotechnology, VIT, Vellore.
  5. Member – Board of Studies ( Marine Biotechnology ) KUFOS –Kerala University of Fisheries and Ocean Studies, Panangad, Kochi.
  • INTERNATIONAL
  1. Member – PhysarumPlus.org – International community of scientists researchers of Physarum polycephalum and other slime molds
PROJECTS HANDLED
Title : ‘Screening for antiproliferative and G2 abrogating activity in endemic species of Zingiberaceae family of plants using Physarum polycephalum and human normal and cancer cell lines’.
Duration                   : 2012-2015
Funding Agency       : DBT ( Govt. of India)
Amount Sanctioned : Rs. 47.39 lakhs
 
PUBLICATIONS :        53
BOOKS AUTHORED: Nil

Details of Publications/Accession nos of DNA sequences submitted in GenBank ( Natl. Centre for Biotech. Information, USA) / Conferences



 Sl No
 
 

 
1
Analysis of β-lactamase, bla NDM-1 phylogeny and plasmid replicons in multidrug resistant Klebsiella Nithya N, Rabindran R, jayasree P R, Faisal M and  Kumar P R M Indian Journal of Medical research ISSN 0971-5916,  2017, Wolters Kluwer Publication  (Accepted, In Press).  Thomson Reuters - Impact factor 1.532
 2Selective induction of DNA damage, G2 abrogation, and mitochondrial apoptosis by leaf extract of traditional medicinal plant Wrightia arborea in K562 cells. T. Lakshmipriya, T. Soumya, P. R. Jayasree, P. R. Manish Kumar.  Protoplasma  ( Springer Publication) – July 2017 (Doi:10.1007/s00709-017-1137-5) . Thomson & Reuters - Impact factor-2.87
3
Antioxidant, antimicrobial and antiproliferative activities of Indian traditional medicinal plant Wrightia arborea leaves. Lakshmipriya T., Soumya T., Jayasree P.R. and Manish Kumar P.R.  March 2017, International Journal of Pharmaceutical Science and Research Vol. 8(3): 1124-1133.2017.  Impact factor-1.7
4
Phytomediated synthesis of silver nanoparticles from Annona muricata fruit extract, assessment of their biomedical and photocatalytic potential. V.S.Shaniba, Ahlam Abdul Aziz, P.R. Manish Kumar.  Jan 2017, International Journal of Pharmaceutical Science and Research, Vol.8(1):1000-12.  Impact factor 1.7
 5Evaluation of total phenolics, antioxidant and antiproliferative activities of rhizome extracts from select Zingiberaceae species in South India. Soumya T., Lakshmipriya T., Jayasree P.R. and  Manish Kumar P.R.  Nov 2017, International Journal of Phytomedicine,  8(2016)337-342, Impact factor 1.06
  Name and Designation Short Title Co author if
any
 Journal / Conference
 Date of
Publica
tion
 Impact
Factor
 6 Dr.
P.R.Manish
Kumar
Associate
Professor
Detection and
prevalence of efflux
pump-mediated drug-
resistance in clinical
isolates of multidrug-
resistant Gram-
negative bacteria from
north Kerala, India.
Manju Suresh,
Nithya,N.,
Jayasree P.R.
Asian Journal of
Pharmaceutical
and Clinical
Research
 2016 0.74
 7 Dr.
P.R.Manish
Kumar
Associate
Professor
Detection of blaNDM-1
and genetic related-
ness in clinical isolates
of Escherichia coli
producing Extended
spectrum β-lactamase
from tertiary care
centres in South India
N. Nithya,
Manju Suresh,
Jayasree P. R
Advances in
Microbiology
 20160.98
 8  Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain
EGE14 class 1 integron,
partial sequence,
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R.
ACCESSION
KU751767
2016
 
9
  Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain
EGE20 class 1 integron,
partial sequence
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R.
ACCESSION
KU751768
2016
 
 10   Dr.
P.R.Manish
Kumar
Associate
Professor
Klebsiella sp. EGE5 class
1 integron, partial
sequence
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
ACCESSION
KU751769.
 2016 
 11  Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain
EGE25 class 1 integron,
partial sequence
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
ACCESSION
KU751770.
2016
 
12
Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain
EGE26 class 1 integron,
partial sequence
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
ACCESSION
KU751771.
2016
 
13
Dr.
P.R.Manish
Kumar
Associate
Professor
Klebsiella sp. K27 New
Delhi metallo-beta-
lactamase (blaNDM)
gene, partial cds
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
 ACCESSION
KX090027
2016
 
 14 Dr.
P.R.Manish
Kumar
Associate
Professor
Klebsiella sp. K28 New
Delhi metallo-beta-
lactamase (blaNDM)
gene, partial cds
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
ACCESSION
KX090028
2016
 
 15 Dr.
P.R.Manish
Kumar
Associate
Professor
Klebsiella sp. K1 New
Delhi metallo-beta-
lactamase (blaNDM)
gene, partial cds
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
ACCESSION
KX090029.
2016
 
16
 Dr.
P.R.Manish
Kumar
Associate
Professor
 Klebsiella sp. K13 New
Delhi metallo-beta-
lactamase (blaNDM)
gene, partial cds
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
 ACCESSION
KX090030
2016
 
 17 Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain E7
New Delhi metallo-beta-
lactamase (blaNDM)
gene, blaNDM-1 allele,
partial cds
 Nithya,N., Manju,S.,
Jayasree,P.R.,
ACCESSION
KX100581
2016
 
18
 Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain E8
New Delhi metallo-beta-
lactamase (blaNDM)
gene, partial cds
 Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R.
ACCESSION
KX100582.
2016
 
19
 Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain
E10 New Delhi metallo-
beta-lactamase (blaNDM)
gene, partial cds
 Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R.
ACCESSION
KX100583
2016
 
 20 Dr.
P.R.Manish
Kumar
Associate
Professor
Escherichia coli strain
E23 New Delhi metallo-
beta-lactamase (blaNDM)
gene, partial cds
Nithya,N., Remitha,R.,
Manju,S.,
Jayasree,P.R
ACCESSION
KX100584.
2016
 
21
    Dr.
P.R.Manish
Kumar
Associate
Professor
 Drug resistance, Biofilm
formation and
occurrence of
mrkABCDF operon in
plasmid-bearing clinical
isolates of E.coli and
Klebsiella spp.from
Kerala,
India.
 Nithya N,
Lakshmipriya
T,Jayasree PR
 Research Journal of
Pharmaceutical,
Biological and
Chemical Sciences
6:1044-1049. ISSN
0975-8585
 2015 0.33
22
 Dr.
P.R.Manish
Kumar
Associate
Professor
 Zerumbone induces
mitochondria-mediated
apoptosis via increased
calcium, generation of
reactive oxygen
species and
upregulation of soluble
histone H2AX in K562
chronic myelogenous
leukemia cells.
 Iyyappan
Rajan,
Jayasree P. R
Tumor Biol (Published
online May 31,
(Springer: DOI:
10.1007/s13277-015-
3583-z)
2015
 3.611
 23 Dr.
P.R.Manish
Kumar
Associate
Professor
 Assesment of cell
cycle phase specific
effects of zerumbone
on mitotically
synchronous surface
cultures of Physarum
polycephalum.
Iyyappan
Rajan, Remitha
Rabindran,
Nithya
Narayanan,
Lakshmi T,
Jayasree P. R
Protoplasma
(Springer: DOI:
10.1007/s00709-013-
0605-9)
 20143.171
 24 Dr.
P.R.Manish
Kumar
Associate
Professor
Antioxidant potential
and oxidative DNA
damage preventive
activity of unexplored
endemic species of
Curcuma
 Iyyappan
Rajan, Remitha
Rabindran,
Jayasree P. R
 Indian Journal of
Experimental Biology
52:133-138
 2014 0.853
 25Dr.
P.R.Manish
Kumar
Associate
Professor
 Zingerone Protects
Against Stannous
Chloride-Induced and
Hydrogen Peroxide-
Induced Oxidative DNA
Damage In Vitro.
 Iyyappan
Rajan, Nithya
Narayanan,
Remitha
Rabindran,
P.R. Jayasree
 Biological Trace
Element Research
(Springer:155:455–
459, DOI 10.1007/S
12011-013-9801-X)
 20131.6
 26Dr.
P.R.Manish
Kumar
Associate
Professor
 Cell cycle inhibitory
effects of leaf extract
from Curcuma vamana
M. Sabu & Mangaly on
mitotically synchronous
cultures of Physarum
polycephalum Schw.
Rajan Iyappan,
Remitha
Rabindran,
P.R. Jayasree
Indian Journal of
Experimental Biology
51: 81-87
2013
0.753
 27 Dr.
P.R.Manish
Kumar
Associate
Professor
 Involvement of 53 kDa
protein in wortmanninmediated
abrogation of
UV-induced G2 arrest
in Physarum
polycephalum
 Rabindran
Remitha M,
Iyappan Rajan,
Jayasree P R
 International.Journal
of Integrative Biology
vol.13, 2, p64-70
ISSN (online): 0973-
8363,ISSN (print):
0974-2816
 Aug.,2
012
 ISSN
(print):
0974-
2816
 28 Dr. P.R.Manish Kumar Associate Professor Physarum polycephalum strain McArdle unknown sequence
Jayasree P.R. and Rabindran R.M.
 Accession no. EU371923.1.  
 29 Dr.
P.R.Manish
Kumar
Associate
Professor
 In vitro antibacterial
activity of Psidium
guajava Linn. Leaf
extract on clinical
isolates of multidrugresistant
Staphylococcus aureus
 Anas K,
Jayasree P R,
Vijayakumar T
Indian Journal of
Experimental Biology
46: 41(2008)
2008
0.599
 30 Dr.
P.R.Manish
Kumar
Associate
Professor
 Ethanolic extract of
Bacopa Monniera
(Brahmi) induces
shortening of cell cycle
durations in naturally
synchronous
Physarum
Polycephalum
 Venu T,
Vishwandham
D, Jayasree
P.R
Curr. Sci. 85:3, 245.
 20030.83
 31 Dr.
P.R.Manish
Kumar
Associate
Professor
 The plasmodia of
Physarum
polycephalum an
elegant system to
demonstrate the
importance of genome
integrity in traversing
the G2/M checkpoint of
the cell cycle
Jayasree P.R
Nair V.R
Curr. Sci. 78:9 101
 2000 0.512
 32 Dr.
P.R.Manish
Kumar
Associate
Professor
 Synergistic effect of
Griseofulvin and
ultraviolet irradiation on
mitotic cycle durations
in the plasmodia of
Physarum
polycephalum,
Nair V.R
 Biomedical letters
( Faculty Press,
Cambridge, England)
48,137.
 1993 
 33Dr.
P.R.Manish
Kumar
Associate
Professor
 A Comparative study of
mitotic delay and
inhibition of
transcription in cells
exposed to UV and
heat shock: the
possible use of mitotic
delay duration as a
parameter to assay the
extent of damage and
recovery
 Nair V.R Curr. Sci. 62:3, 314. 1992 0.253
 34 Dr.
P.R.Manish
Kumar
Associate
Professor
 Synergistic effect of
heat-shock and UV
irradiation on mitosis
and protein synthesis in
G2 phase plasmodia of
Physarum
polycephalum schw.
reduction in UV induced
mitotic delay in a pre
shocked system
 Nair V.RIndian J. Exp. Biol. 29,
305.
1991
0.753
 35 Dr.
P.R.Manish
Kumar
Associate
Professor
 Effect of heat shock on
the different phases
of the mitotic cycle in
Physarum
Polycephalum
 Nair V.R Curr. Sci. 59:12,615 19900.253
 Conference papers
 36Photocatalytic dye degradation and enhanced biopotentials of annona muricata mediated zinc oxide nanoparticles Ahlam Abdul Aziz, V.S.Shaniba,  P.R. Manish Kumar National seminar on emerging trends in chemical research, Christ college, Irinjalakuda 28 Feb- 1 Mar 2017
 37Phytomediated synthesis of photocatalytically active zinc oxide nanoparticles from fresh flowers of Cassia fistula Ahlam Abdul Aziz, V.S.Shaniba, Dr. P.R. Manish Kumar International conference on advances in functional materials (ICAFM) Anna University, Chennai,  Jan 6-8, 2017
 38Investigations on the biomedical potential of green synthesized silver nanoparticles. V.S.Shaniba, Ahlam Abdul Aziz, P.R. Manish Kumar. National seminar on emerging trends in chemical research, Christ College, Irinjalakuda, 28 Feb- 1 Mar, 2017.
 39Green  synthesis of silver naoparticles employing Manikara zapota leaf extract and evaluation of their antioxidant activities. V.S.Shaniba, Ahlam Abdul Aziz, P. R. Manish Kumar. International Conference on Advances in Functional Materials (ICAFM)Anna University, Chennai, Jan 6-8, 2017
 40Antiproliferative activity and phytochemical analysis of organic solvent extractions from Curcuma mutabilis rhizome. Soumya T., Lakshmipriya T.,Jayasree P.R., Manish Kumar P.R.International  36th Annual conference of Indian Association for Cancer Rresearch (IACR-2017), Amala Cancer Research Centre, Thrissur, Feb-9-11, 2017
 41Enhancement of demethoxycurcumin mediated cell death by the checkpoint kinase inhibitor PD 407824 in K562 leukemic cell line – a preliminary report. Soumya T Lakshmipriya T.,Jayasree P.R., Manish Kumar P.R.  (National) 29th Kerala science congress, Marthoma college, Thiruvalla, Pathanamthitta, 28-30 Jan, 2017.
 42Selective killing of  human chronic myelogenus leukemic K562 cells by Drakshadi kashayam, an Ayurvedic formulation. Lakshmipriya T., Soumya T.,Jayasree P.R., Manish Kumar P.R. International 36th Annual conference of Indian Association for Cancer Research (IACR-2017), Amala Cancer Research Centre, Thrissur, Feb-9-11, 2017
 43Selective killing of  human chronic myelogenous leukemic cells by a bioactive fraction isolated from leaves of the ayurvedic medicinal plant Tridax procumbens. Lakshmipriya T., Soumya T.,Jayasree P.R., Manish Kumar P.R. (National) , 29th Kerala Science Congress, Marthoma college, Thiruvalla, Pathanamthitta, 28-30 Jan, 2017.
 44 Dr.
P.R.Manish
Kumar
Associate
Professor
Antiproliferative
activity
of
Curcuma
mutabilis
rhizome
extracts against human cancer cell
lines.
Soumya T.,
Lakshmipriya T.,
Jayasree P.R.
National seminar
on drug-discovery
and cancer therapy
– Dept. of
Biochemistry and
Molecular Biology,
Pondicherry
University
25-26
Feb 2016
 
 45Dr.
P.R.Manish
Kumar
Associate
Professor
Prevalence and rapd analysis of
various beta-lactamases- esbl,
ampc and mbl - among multi drug
resistant Pseudomonas aeruginosa
clinical isolates from north Kerala
Manju Suresh
28 Th Kerala
Science Congress,
University of
Calicut
Jan
28-30
2016
 
 46 Dr.
P.R.Manish
Kumar
Associate
Professor
Green synthesis and
Characterization of siver nano
Particles from Manikara
zapota leaf broth
Shaniba V.S,
Ahlam Abdul
Aziz.
UGC sponsored
National level
conference on
sustainable
Biotechnology,
E.M.E.A College of
Arts and Science,
Kondotti

Dec
16-17

2015

 
47
Dr.
P.R.Manish
Kumar
Associate
Professor
Antioxidant and
Antiproliferative
activities
of different organic
extracts of Curcuma
rakthakanta rhizome
and leaf
Soumya T.,
Anju Lata
Singh.,
P.R.Jayasree
 UGC sponsored
National seminar on
Recent developments
in Cancer Biology,
Organized by
Department of
Lifesciences
,Pazhassiraja
College,Pulpally,
Wayanad.
 22-24
July
2015
 
 48 Dr.
P.R.Manish
Kumar
Associate
Professor
Sol-gel synthesis and
characterization of zinc
nanoparticles from
leaves of Annona
muricata.
 Ahlam Abdul
Aziz, Shaniba
V. S.,
Kerala Science
Congress, Allappuzha,
 Jan 27-
31
2015
 
 49Dr.
P.R.Manish
Kumar
Associate
Professor
 Green synthesis of
silver nano particles
from
Annona muricata
root extract and its
antimicrobial activity.
Shaniba V. S.,
Ahlam Abdul
Aziz
International
Conference on
Biosciences – Stateof-
the-art
Advancements
( Proceedings of the
Society for Education
and Scientific
Research ), Kottayam.
P. 76.
 Sept.
11 –
12.
2014
 
 50 Dr.
P.R.Manish
Kumar
Associate
Professor
In vitro screening
of antimicrobial activity
of Wrightia arborea
against clinical isolates
of multi- drug resistant
bacteria
Lakshmipriya
T., Nithya N.,
Jayasree P. R
 International
Conference on
Biosciences – Stateof-
the-art
Advancements (
Proceedings of the
Society for Education
and Scientific
Research ) Kottayam..
P. 110.
 Sept.
11 – 12
2014
 
 51Dr.
P.R.Manish
Kumar
Associate
Professor
 PCR- based screening
to detect the prevalence
of Class I integron in
meropenem-resistant
clinical bacterial isolates
 Nithya N.,
Rajan I.,
Lakshmipriya
T., Jayasree P.
R
 Kerala Science
Congress Wayanad
 Jan 28-
31
2014
 
 52 Dr.
P.R.Manish
Kumar
Associate
Professor
 Antioxidant, DNA
protective activity
and cellular effects
of leaf extracts
from Curcuma species
(Zingiberaceae)
endemic to South India
Rajan Iyappan,
Remitha
Rabindran,
P.R. Jayasree
6th International
Symposium on the
family Zingiberaceae,
Sept 10 – 13,
University of Calicut,
Organized by
Department of Botany,
University of Calicut &
Indian Association for
Angiosperm
Taxonomy
 Sept 10
– 13
2012
 
53
 Dr.
P.R.Manish
Kumar
Associate
Professor
Stannous chloride
induced DNA damage
protecting activity and
antioxidant potential
of aqueous leaf
extracts of
Curcuma vamana,
an endemic
Zingiberaceae
plant from Kerala.
 Rajan Iyappan,
Remitha
Rabindran,
P.R. Jayasree
International
Symposium on
innovations in Free
Radical Research and
Experimental
Therapeutics &5th
Annual Convention of
Association of
Biotechnology and
Pharmacy, Organized
by Department of
Biotechnology &
School of
Biotechnology and
Health Sciences,
Karunya University,
Coimbatore
 Decem
ber 7-9
2011
 


HONOURS & AWARDS
  1. Awarded JRF & SRF of C.S.I.R.; DBT- RA
  2. Awarded ‘Best Subject Expert for the year 2000’ by University Grants Commission for the Educational video on DNA Fingerprinting entitled ‘DNA evidence’ produced by Audiovisual Research Centre ( AVRC)(EMMRC) University of Calicut
RESEARCH GUIDANCE
  • Ph. D. Degree : Awarded Degree: 3

                                 In progress :5

  • M.Phil. Degree : Awarded Degree: 3
  • External Examiner for Ph.D. Thesis : 6
 
MEMBERSHIP IN THE UNIVERSITY ACADEMIC BODIES:
  1. Served as Chairman, Board of studies ( Single Board) in Genetics, Univ. of Calicut
  2. Member – Board of Studies in Biotechnology, Univ. of Calicut.
  3. Served as DBT (Govt. of India) nominee – Institutional Biosafety Committee - at Indian Institute of Spices Research (IISR), Calicut.
  4. External subject Expert nominee– Research Admission Committee – IISR, Calicut; Department of Biotechnology, VIT, Vellore.
  5. Member – Board of Studies ( Marine Biotechnology ) KUFOS –Kerala University of Fisheries and Ocean Studies, Panangad, Kochi.
 

Last Updated ( Tuesday, 19 September 2017 )