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Radhakrishna G Pillai

Lecturer

 

 Department of Life Sciences, University of Calicut, CU PO, 673635

Phone: Mobile 9495554891
Email:    This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 

 
Qualifications
MSc (Zoology), PhD Biochemistry,
MSc (Bioinformatics- London), LLB, BEd, PGCE, PGDDE
Professional trainings
1. Neuro Linguistic Programming             NLP Academy, London                         Jan 2010
2. Certificate in First line Management      Chartered Management Institute          June 2006
3. Community volunteering                        ASDAN London                                    April 2006

Specialisation:             Stem cell technology, Genetic Engineering, Imaging technology
Achievements:
Fellowships: International:    1. Post doctoral fellowship- University of California San Diego
                                                     2. Action Research – Post doctoral fellowship, UK
                                                     3. Cancer Research UK Post doctoral Fellowship
                       National:             1. UGC JRF
                                                     2. CSIR SRF
Membership/Professional affiliation
National:                                     1. Life member- Society of Biological Chemists India
                                                      2. Life member, Indian Society of Comparative Animal Physiology

International              1. Member, European Association for Cancer Research
                                      2. Member, British Association of Cancer Research
Membership in Academic bodies
         1. Member of Board of Studies in Physiology, University of Calicut- 1997-
         2. Member of Board of Studies in Environmental Science, University of Kerala- 1998-
         3. Member of Board of Studies in Biochemistry, University of Kerala – 1999-
Membership in Editorial Boards
              1. Editor, Journal of Aids and HIV Research (2011 –current)
              2. Editor, Journal of Life Sciences (1994-96)
              3. Executive Editor, Research Review (1990-96)
              4. Reviewer –Journals under Bentham Science Publishers, USA
              5. Reviewer- Indian Journal of Medical Research
              6. Reviewer- Journal of anticancer research
Visiting Professorship
 Institute of Medical Sciences, Kirgistan

Travel
       USA, Mexico, UK, Russia, Singapore, Malaysia, Sri Lanka, Kirgistan and Indonesia

Research areas:

Stem cell mediated therapy for degenerative diseases: This projects aims in the identification of natural products that could enhance the rate of proliferation, mobilisation, homing and differentiation of stem cells. The idea is from our age old system of medicine- the Ayurveda which uses a number of plant derived medical formulations for regeneration of degenerated tissue and healing of wounds. In my laboratory a few plants, the extracts of which are found to have stem cell modulatory activities are identified. One project looks into the mode of action of these plant derived materials in modulating stem cells. Successful completion of this project will lead to the development of certain food materials or drugs that could be used to mobilise stem cells for the treatment of degenerative diseases like diabetes and cardiomyopathy.


Use of bone marrow derived stem cells for treatment of diabetes and defects in vision is being investigated.


Waste management and formation of value added products:


Another researcher is working on the possible development of waste management technologies by using algae. Algae from various ecosystems around the University will be collected and identified. Their ability to digest waste will be studied. The algae grown in the wastes will be collected and the possibility of developing values added products will be explored. The growing algae also help in carbon sequestration.

Use of locally available plants in reducing the effects of poverty and related diseases:


A few students are actively investigating on the possibility of identifying a few locally growing wild plants that could be used to alleviate anemia. A number of plants are identified to have anemia reducing properties. Now we are in the process of identifying their physiological and biochemical roles in alleviating anemia. This project will be defining different doses needed to treat anemia of varying degrees. The possible toxic effects of these plant products will also be studied.

Projects Handled
       Total numbers:            5
   1. Title: Investigations on the Bioremediation of gold industry effluents using bacteria
       Funding agency: UGC
       Amount : 5 lakhs
       Year : 1999
   2. Title: Effect of heat shock proteins on protecting cardiomyocytes
       Funding agency: STEC
       Amount: 2 lakhs
       Year: 1999
   3. Title: Developing virus mediated methods for suppressing allogenic response in organ recipients
       Funding agency: Action Research
       Amount: 75 lakhs
       Year : 2001
   4. Title: Investigations on the pharmacokinetics of BGC945
       Funding agency:
       Amount: 95 lakhs
       Year: 2004
   5. Title: Investigations on the Development of effective Biogas Technology for the high ranges of
       Kerala- a translational project using biotechnology for the benefit of the tribes of Wayanad
       Funding agency: Kerala State Planning Board
       Amount: 9.9lakhs
       Year: 2014

Selected recent publications
  1. Pillai RG., Bone marrow derived stem cells and stem enhance 2 (SE2) protects diabetic rats , Proceedings of the National Seminar on Emerging Trend in Biotechnology, Cochin 2014, 84- 95.
  2. Pillai RG., Stem Cells For Ocular Tissue Engineering and Regeneration, Curr Top Med Chem. 11(13):1606-20, 2011.
  3. Pillai RG., Redasoft cloning vector- a review: Journal of Immunological Methods, 276:243-244, 2003.
  4. Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, Golovko O, Jackman AL, Aboagye EO. Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945. Cancer Res. 2008, 15;68(10):3827-34.
  5. Pillai RG, Beutelspacher SC, Larkin DF, George AJ. Expression of the chemokine antagonist vMIP II using a non-viral vector can prolong corneal allograft survival. Transplantation. 2008,15;85(11): 1640-7.
  6. Pillai RG, Beutelspacher S, Larkin F and George ATJ Upregulation of chemokine expression in murine cornea due to mechanical trauma or endotoxin. Br J Ophthalmol. 2008 Feb;92(2):259-64.
  7. Alam AK, Florey O, Weber M, Pillai RG, Chan C, Tan PH, Lechler RI, McClure MO, Haskard DO, George AJ, Knockdown of mouse VCAM-1 by vector-based siRNA.Transpl Immunol. 2006, 16(3-4):185-193.
  8. Meg Perumal, Pillai RG, Henryk Barthel, John R. Latigo, Martin Forster, Ann L. Jackman, and  Eric O. Aboagye, Redistribution of Nucleoside Transporters to the Cell Membrane Provides a novel Approach for Imaging Thymidylate Synthase Inhibition by Positron Emission Tomography.Cancer Res. 2006, 66(17): 8558-8564.
  9. Leyton J, Alao AJ, Marco Da Costa, Latigo JL, Perumal M, Pillai RG, He Q, Atadja P, Lam EWF, Workman P, Vigushin DM and Aboagye EO. The Histone Deacetylase Inhibitor LAQ824 Inhibits Cellular Proliferation in HCT116 Xenografts as Determined by 3’-Deoxy-3’- [18F]fluorothymidine Positron Emission Tomography (FLT-PET). Cancer Res. 2006, 66(15):7621-7629.
  10. Yau K, Price P, Pillai RG, Aboagye E., Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase  inhibitors. Eur J Nucl Med Mol Imaging. 2006; 33(9):981-7.
  11. Beutelspacher SC, Pillai RG, Watson MP, Tan PH, Tsang J, McClure MO, George AJT and Larkin DFP., Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression., Eur J Immunol. 2006, 36(3):690-700.
  12. Pillai RG et al Induction of apoptosis in human lung cancer cells by Curcumin, Cancer Lett. 2004, 208(2):163-70.

 
 
 

Last Updated ( Wednesday, 12 August 2015 )