Through teaching and research, the 25 post graduate departments of the University have made a mark in their respective areas. While some of them have been chosen for collaboration and funding to undertake research projects by external funding agencies, a substantial number of the faculty of these Departments have been conferred with prestigious fellowships by national and international bodies.

It was in recognition of their potential to extend their expertise in the emerging areas of education, training and extension, that the University Grants Commission funded the establishment of the Academic Staff College in 1987 and the Audio Visual Research Centre in 1996 on the main campus of the University Similarly, the Department of Biotechnology, Govt. of India, funded the University to set up the Department of Biotechnology in 1995. Some of the Departments have been successfully publishing scholarly journals. The journals are: Calicut University Research Journal, Interventions, The Malabar, Journal of South Indian History, Ruchi and Malayala Vimarsam.

With restructured syllabi and well equipped laboratories and libraries, the Departments offer a variety of post graduate programmes that meet the changing demands of the academic and industrial sectors. In addition to these 25 departments, the University has set up a School of Health Sciences and a Computer Centre that offer graduate and post graduate courses in their respective areas.